Research
Research in the Pyott Lab investigates function of the inner ear and the connections between the inner ear and the brain. By studying the biology of hearing and balance at multiple levels—from molecules and cells to neural circuits—we aim to understand how the inner ear functions and how sensory input shapes brain and behavior.
Our work combines various molecular techniques, including in vitro and in vivo electrophysiology, immunofluorescence, single-molecule RNA detection, and RNA sequencing, with behavioral assessments. This approach allows us to explore the function of the inner ear and the impact of sensory input and loss of sensory input on the brain.
Using the mouse as a genetically versatile and clinically relevant model as well as other less commonly used rodent models, we connect peripheral and central processes to build a comprehensive understanding of hearing and balance. Our research provides valuable insights into the pathways that underlie these remarkable senses and directs innovations to combat loss of function.
Core Areas of Research
1. Channels and transporters as regulators of excitability in the inner ear
2. Form and function of inner ear synapses
3. Integration of afferent and efferent circuits in the inner ear
4. Influence of auditory input on the brain